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Selection, Preparation and Storage of Lyophilization Stoppers for Moisture-Sensitive Drug Products

Drying of closures prior to filling is important, but the rubber formulation and its MVTR are critical to reduce the moisture uptake from the environment.
There are several ways by which water vapor could reach freeze-dried drug products inside a closure container system. Selecting the right lyophilization stopper to achieve a seal integrity of stopper-to-vial combination requires aligning the following requirements...

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