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West's Applied Research Team will be presenting two scientific posters at the upcoming International Society for Cell and Gene Therapy 2021 New Orleans Annual Meeting taking place online May 26 – 28, 2021.
Therapeutic gene delivery viral vectors and living cell-based drugs often require storage at ultra-cold and cryogenic temperatures, respectively, to maintain their potency as low temperature storage effectively slows natural degradation processes. In two proof-of-concept studies, we tested our COP-based container systems to do just that – safely store and efficiently recover an AAV2 viral vector and an expanded T cell culture in ultra-cold and cryogenic temperatures, respectively. We then monitored recovery of product from the containers and functional attributes like transduction and outgrowth potential.
Poster #1109 entitled “EVALUATION OF A NOVEL CYCLIC OLEFIN POLYMER CONTAINER SYSTEM FOR STORING ADENO-ASSOCIATED VIRUS” details various vialing configurations that each enable consistent recovery of AAV2 viral particles, which retain their functional ability to transduce HEK293 cells through higher vector recovery compared with glass containers.
Poster #1243 entitled “COMPARISON OF RIGID POLYMER VIALS AND FLEXIBLE BAGS FOR THE CRYOPRESERVATION OF T CELLS” demonstrates that COP-based rigid container systems provide consistent recovery of viable and functional T Cells without altering the outgrowth cell population – a requisite of a reliable cell therapy manufacturing and administration process.
These studies provide an exciting proof-of-concept for rigid vial systems enabling better drug product recovery while retaining functional characteristics that viral vectors and cell therapies require.Visit our posters #1109 and #1243 at the ISCT 2021 New Orleans Annual Meeting.
The research posters and technical reports detailing the collaborative work will be available for download from our Knowledge Center after the event.
Why is meeting customer needs no longer enough? In an expanding global economy with international competition, meeting customer needs is simply not enough. Meeting customer needs leads to customer satisfaction but does not lead to customer loyalty, which is what keeps companies in business.
For 10 years, West has offered a summer internship in many of its U.S. locations. The Ambassador Internship Program has grown from hiring two interns in its first year to hiring 38 interns in 2018. <br />
West employees have forged a strong bond with many of the local organizations they support through the West without Borders fundraising initiative.
The need for <a href="/sitecore/service/notfound.aspx?item=web%3a%7b8E02CCA4-F229-4EDC-93A4-6A837E7FA55E%7d%40en">advanced containment solutions</a>, and novel fill-finish processing to enable implementation of these solutions, continues to grow as more complex drug products enter multiple pipelines. As biotech companies develop these complex drug products, the integration of product and process knowledge is crucial to delivering product safety, quality, identity, potency, and purity. And as biotech companies seek partners to help accelerate their development processes, West is committed to leading multi-disciplined, high-performance teams in developing optimal fill-finish solutions for novel packaging and container systems. This dynamic partnership is well-illustrated by the following case study.
Combination products open up new vistas when it comes to delivering innovative therapies to patients in need, but teams bringing these products to the market face a number of significant hurdles. Recent surveys conducted by West at workshops held in PA and AZ have revealed some of our customers’ biggest challenges. This is the second of three blogs focused on these challenges — and how West can help Simplify the Journey™ when it comes to developing a combination product.
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